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The effect of pesticides on Parkinson’s disease :New research shows how pesticides (paraquat and manb) alter gene expression and may lead to Parkinson’s disease in people who are genetically predisposed. Estimates show that about 50,000 people are diagnosed with Parkinson’s in the United States each year.
Environmental factors, such as pesticides, may affect your risk of Parkinson’s disease.
In the 1980s, studies were conducted that showed that early-age exposure to a rural environment as well as exposure to well water were associated with development of PD later in life. Subsequently, multiple additional studies looked at these questions. The studies are mixed in their conclusions, but overall the evidence supports associations between increased Parkinson’s disease “PD” risk with each of the following:
Although the exact cause of this disease is not known, both genetic and environmental factors play an important role. The National Institutes of Health (NIH) notes that exposure to pesticides increases the risk of developing Parkinson’s.
Older studies have also shown that pesticides, especially paraquat and maneb, can extend the risk of Parkinson’s disease in people who are genetically predisposed. Recent studies have sought to decipher the neural mechanisms involved in the relationship between pesticides and neurodegenerative states.
For example, some studies have shown that pesticides interfere with neurogenesis. Neurogenesis; It is a process in which the brain creates new neurons. The hippocampus of the brain is a key area for memory and information processing.
Pesticides work by causing genetic changes. Now, a new study by researchers at Golf University in Ontario, Canada, reveals some of the ways in which pesticides cause genetic mutations that lead to neurodegeneration.
Scott Ryan; The professor of molecular and cellular biology at the university explains the motivation behind the research. “People who are exposed to these chemicals are about 250 percent more likely to develop Parkinson’s disease than the rest of the population,” he said.
Parkinson‘s disease is a progressive disorder of the nervous system that affects movement. The symptoms start gradually and sometimes start with just a small tremor in one hand, which is difficult for the person to notice. In addition to the tremors that are very common, this disorder usually causes dryness or slowness of movement
In the early stages of Parkinson’s disease, facial expressions may be mild. Hands may not move when walking. The person may speak quietly or vaguely. The symptoms of Parkinson’s disease get worse as the disease progresses.
Although Parkinson’s disease is incurable, medications may significantly improve your symptoms. Sometimes a neurologist may suggest surgery to adjust specific areas of the brain and improve symptoms.
The signs and symptoms of Parkinson’s disease can be different for everyone. Early symptoms may be mild and insignificant. Symptoms often start on one side of the body and are usually more severe on the first side, even after symptoms on both sides.
Vibration usually starts in an organ, often the hand or fingers. The person may rub their thumb and forefinger together, which is called a rolling cell vibration. There may be tremors at rest.
. Over time, Parkinson’s disease may slow down and make simple tasks difficult and time consuming. The person’s steps become shorter when walking. It becomes difficult to get up from the chair. The person puts his feet on the ground while walking.
Muscle stiffness can occur in any part of the body. Hard muscles can be painful and limit the range of motion.
The person may become bent or may have difficulty balancing.
The ability to make unconscious movements, such as blinking, smiling, or moving the hands while walking, may decrease.
Speech may be slow, fast, vague, or hesitant, and may be more monotonous without the usual ups and downs.
The cause of Parkinson’s disease is unknown, but various factors appear to be involved, including:
Genetics. Researchers have identified specific genetic mutations that can cause Parkinson’s disease. But these are not uncommon, except in rare cases where many family members have Parkinson’s disease.
Although specific gene variations appear to increase the risk of Parkinson’s, the risk is very low for each of these gene markers.
Environmental stimuli. Exposure to certain toxins or certain environmental factors may increase the risk of Parkinson’s disease in the future, but the risk is relatively low.
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